Major Completed Programs

Genetic Association Information Network (GAIN)

In 2007, the Genetic Association Information Network (GAIN) completed an ambitious program to genotype existing research studies in six major common diseases, and combine the results with clinical data to create a significant new resource for genetic researchers. The network’s goal was to help find genetic causes for common diseases, and its initial efforts focused on Attention Deficit Hyperactivity Disorder, diabetic nepropathy in Type I diabetes, major depression, psoriasis, schizophrenia and bipolar disorder.

The Osteoarthritis Initiative

Launched in 2002 and completed in 2015, the Osteoarthritis Initiative (OAI) represents a collaboration of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA) and the private sector, working together to improve the efficiency of drug development and clinical trials for the treatment of OA.

Grand Challenges in Global Health

Grand Challenges in Global Health (GCGH) was launched by the Bill & Melinda Gates Foundation in 2003 as a collaboration with the FNIH—and later also with the Wellcome Trust and the Canadian Institute of Health Research—as a major initiative focused on achieving scientific breakthroughs against diseases that kill millions of people each year in the world’s poorest countries.