In any given year, one in four Americans suffers from a mental illness. It is a major burden on individuals and society; in fact, the direct and indirect costs of mental illness may top $270 billion annually. Effective treatments have been elusive for many disorders, but research continues to illuminate new possibilities.

The Sports and Health Research Program (SHRP) is an innovative partnership among the National Institutes of Health (NIH), the National Football League (NFL) and the FNIH. Launched in 2012, the program aims to help accelerate the pursuit of research to enhance the health of athletes at all levels, past, present and future, and to extend the impact of that research beyond the playing field to benefit others in the general population, including members of the military.

The overarching goal of the consortium is to conduct a rigorous set of analyses of GWAS data for Attention Deficit Hyperactivity Disorder, autism, bipolar disorder, major depression disorder, and schizophrenia, utilizing the knowledge and capabilities of the contributing groups to accomplish analyses that can help move the entire field of mental health genetic research forward.

In 2007, the Genetic Association Information Network (GAIN) completed an ambitious program to genotype existing research studies in six major common diseases, and combine the results with clinical data to create a significant new resource for genetic researchers.

The goal of this multi-year project was to evaluate schizophrenia medications as they relate to indicators for cardiovascular disease and disease stability, and to determine treatment effectiveness.