GENETIC ASSOCIATION INFORMATION NETWORK (GAIN)
 ADHD Genotyping QC Data Now Available
The Genetic Association Information Network (GAIN) is a public-private partnership of the Foundation for the National Institutes of
Health, Inc. (FNIH) that currently involves the National Institutes of Health (NIH), Pfizer, Affymetrix, Perlegen Sciences, Abbott,
and the Eli and Edythe Broad Institute (of MIT and Harvard University). GAIN is taking the next step in the search to understand
the genetic factors influencing risk for complex diseases. Through a series of whole genome association studies, using samples
from existing case-control studies of patients with common diseases, GAIN will contribute to the identification of genetic pathways
that make us more susceptible to these diseases and thus facilitate discovery of new molecular targets for prevention, diagnosis, and
treatment.
GAIN aims to release data as broadly and rapidly as possible, with equal opportunity for access by all potential users. To promote
the responsible use of the GAIN Project Datasets, investigators, and their institutions, seeking access to genotypic or phenotypic data
will submit a Data Access Request Form
and Data Use Certification specifying their intended use of the data and acknowledging their agreement with the terms and conditions described. All investigators, including Collaborating Study Investigators, GAIN Partners, and others, will access the GAIN Project Datasets through the same mechanism.
FNIH is actively seeking additional partners to participate in GAIN Partnerships including corporations, private foundations, and advocacy groups.
On October 10, 2006, following a rigorous five-month selection process, the FNIH’s Board of Directors announced that the first six studies in common diseases have been chosen for genome-wide association analysis at the recommendation of the GAIN Steering Committee. This first phase of GAIN will genotype 18,000 samples from studies in schizophrenia, bipolar disorder, diabetic nephropathy, ADHD, major depression, and psoriasis (see Initial Studies). The genotype and associated deidentified phenotype information from each of the six studies (the GAIN Project Datasets) will be deposited throughout 2007 in a database managed by the National Center for Biotechnology Information (NCBI) for access by the research community.
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